TOXIC BY DESIGN - PART 23. Dr. Mike Yeadon: Another study as evidence of intent to harm. The harmful effects of LNPs were already known before 2020.
Potential adverse effects of nanoparticles on the reproductive system.
Dr. Mike Yeadon, May 13, 2025 :
https://t.me/DrMikeYeadonsolochannel/2860
I do recall seeing this years ago, I think sent to me after we’d published an open letter laying out some severe concerns that Dr Wolfgang Wodarg & I had, prior to mass administration.
There’s a much earlier (2012) paper which summarized the preferential deposition of lipid nanoparticle (LNP) formulations into reproductive tissues, particularly the ovaries. This 2018 paper is every bit as bad. No one knowing of this would elect to use LNP to formulate anything to be given to entire human populations without let or hindrance, unless they intended harms as a result.
This isn’t arcane knowledge in an obscure journal. The 2012 review was in a main journal that those working in the pharmaceutical development side of industry would see.
Best wishes
Mike
Linked :
https://pubmed.ncbi.nlm.nih.gov/30587973/
Review - Int J Nanomedicine. 2018 Dec 11:13:8487-8506.
doi: 10.2147/IJN.S170723. eCollection 2018.
Potential adverse effects of nanoparticles on the reproductive system
Abstract
With the vigorous development of nanometer-sized materials, nanoproducts are becoming widely used in all aspects of life. In medicine, nanoparticles (NPs) can be used as nanoscopic drug carriers and for nanoimaging technologies. Thus, substantial attention has been paid to the potential risks of NPs. Previous studies have shown that numerous types of NPs are able to pass certain biological barriers and exert toxic effects on crucial organs, such as the brain, liver, and kidney. Only recently, attention has been directed toward the reproductive toxicity of nanomaterials. NPs can pass through the blood-testis barrier, placental barrier, and epithelial barrier, which protect reproductive tissues, and then accumulate in reproductive organs. NP accumulation damages organs (testis, epididymis, ovary, and uterus) by destroying Sertoli cells, Leydig cells, and germ cells, causing reproductive organ dysfunction that adversely affects sperm quality, quantity, morphology, and motility or reduces the number of mature oocytes and disrupts primary and secondary follicular development. In addition, NPs can disrupt the levels of secreted hormones, causing changes in sexual behavior. However, the current review primarily examines toxicological phenomena. The molecular mechanisms involved in NP toxicity to the reproductive system are not fully understood, but possible mechanisms include oxidative stress, apoptosis, inflammation, and genotoxicity. Previous studies have shown that NPs can increase inflammation, oxidative stress, and apoptosis and induce ROS, causing damage at the molecular and genetic levels which results in cytotoxicity. This review provides an understanding of the applications and toxicological effects of NPs on the reproductive system.
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The author of the following article, Maria Gutschi, describes several properties of LNPs and refers to some study results.
The information about the author comes from Maria Gutschi herself :
Independent researcher. Independent thinker. Ex-regulator for drug pricing. Ex-hospital pharmacy clinical manager. Wife, mother, grandmother, Catholic.
Source : https://substack.com/@mariagutschi?utm_source=about-page
Editor’s note: Please note that this article contains links to articles whose authors continue to spread the "Covid" myth. And one more thing: This article is based exclusively on conventional medicine. For this reason alone, I don't expect all the information here to be accurate. Above all, the distribution of LNPs in the body seems to be much less controllable than this article suggests. I still think the article is interesting :
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The BioCorona
And why it is important and why the measured zeta potential is not
Apr 15, 2025
https://mariagutschi.substack.com/p/the-biocorona
A fragment of the interesting article :
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This new paper describes in great detail, why all LNPs are preferentially accumulated in the liver. Mostly because of the adsorption of ApoE but also because of the liver’s anatomy. The LDL (low-density lipoprotein) receptor is targeted by the ApoE on the LNPs (since ApoE comprises part of LDL). The anatomy of the liver of the sinosoids (blood flow) and passage through fenestrated epithelium into the disse space and then into the hepatocytes where the ApoE coated LNPs can then transfect the hepatocytes.
( … )
Full article :
https://mariagutschi.substack.com/p/the-biocorona
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A sarcastic summary of Maria Gutschi’s article appeared in Telegram :
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Mutflash - Medizinische Argumentationen und Studiensammlungen , April 15, 2025. Here is a translation from German to English :
Source : https://t.me/mspezial/18836
The translation of the name of the Telegram channel into English:
Mutflash - Medical Argumentations and Study Collections
We have a macroscopic problem with the LNP (total formulation) rotation (Brownian motion, thermodynamic drift, convection currents, etc.), which determines the absolutely homogeneous identity of each individual LNP in the stochastic moment of initial contact with biological material such as ions, proteins, and membranes in vivo.
And then there's the orbital electron motion of each individual lipid particle in the LNP formulation.
Oops: Sorry. We inadvertently messed up the entire quantum reality of your cells a bit. Are you mad at us? We really thought it was "safe and effective"™.
Linked :
https://mariagutschi.substack.com/p/the-biocorona
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The lipid nanoparticles are uncontrollable :
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The study shows that LNPs themselves are immunogenic, which can make the B cell response uncontrolled :
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Review Article
Published: 02 October 2023
https://www.nature.com/articles/s12276-023-01086-x
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Study links nanoparticles to oxidative stress and neuron death
July 23, 2024
https://phys.org/news/2024-07-links-nanoparticles-oxidative-stress-neuron.html
The study mentioned in the article linked above :
Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles
First published: 11 July 2024
“ ( … )
3.5 Oxidative stress-induced sEVs transport ceramide to mitochondria and induce cell death
The observation that oxidative stress led to the secretion of ceramide-rich sEVs carrying ASM and nSMase2 prompted us to investigate if (a) secretion of sEVs removes oxidative stress-induced excess ceramide (and SMases) in donor cells and (b) sEVs transport excess ceramide into recipient cells leading to impairment of cell function or even cell death.
( … ).”
Full article / study :
https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.12477
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Warning in '22: Craig Paardekooper Examines the Repeating 7-Day Cycle of Vaccinations and Deaths
Transcript of a censored video of 2022
Feb 19, 2024
“ ( … )
Perhaps we should ask a question. If the vaccine is meant to reduce mortality and protect our health, then why do deaths rise as the number of vaccinated rises, and fall as the number of vaccinated falls, in a weekly cycle that repeats over and over again?
( … ).”
Full article :
https://transcriberb.dreamwidth.org/136690.html
https://transcriberb.substack.com/p/open-a7c
VIDEO :
Source : https://www.bitchute.com/video/7Z6aJ0add9SH/
Seven Day Cycle of Death
March 1, 2022
Text below the video:
The numbers vaccinated follows a 7 day cycle each week - with a minimum number of vaccines being given on a Sunday, progressively more vaccines being administered on Monday, Tuesday and Wednesday, reaching a maximum on Thursday, then declining on Friday and Saturday down to a Sunday minimum. This pattern is repeated every week. I was curious to see if the number of deaths resulting from the vaccines followed a similar pattern. So I counted the number of deaths associated with vaccines given on each day of the week. To do this I looked at each vaccination date and counted the total number of reports for that date which ended in a fatality. I found that the number of deaths correlated very strongly with the number vaccinated on a particular day. The correlation was 0.99 with a probability of 0.046. So, every week, as the number vaccinated rose and fell in a 7 day cycle, the number of deaths also rose and fell in a 7 day cycle, and this pattern persisted throughout the whole of 2021. Perhaps we should ask a question - "If the vaccine is meant to reduce mortality and protect our health, then why do deaths rise as the number of vaccinated rises, and fall as the number of vaccinated falls, in a weekly cycle that repeats over and over again?"
TRANSCRIBER'S NOTES :
Siurce : https://transcriberb.dreamwidth.org/136690.html
"Craig Paardekooper [is] a pharmaceutical sciences student at Kingston University. He is a member of NHS Staff for Choice - a group of 2400 doctors, nurses and research staff who believe that vaccination should be by consent, and there should be no restrictions imposed on those who refuse it." — Source: https://craigpkooper.wixsite.com/vaccine
[2] VAERS is the official US government Vaccine Adverse Event Reporting System.
https://vaers.hhs.gov/about.html
(Note:
https://openvaers.com
provides VAERS data in a more reader-friendly presentation.
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Studies such as “Role of Lipid Peroxidation-Derived α, β-Unsaturated Aldehydes in Vascular Dysfunction” show that oxidized lipids in LNPs can damage endothelial cells (blood vessel walls) :
Role of Lipid Peroxidation-Derived α, β-Unsaturated Aldehydes in Vascular Dysfunction
https://pmc.ncbi.nlm.nih.gov/articles/PMC3683506/
May 30, 2013
Abstract
Vascular diseases are the most prominent cause of death, and inflammation and vascular dysfunction are key initiators of the pathophysiology of vascular disease. Lipid peroxidation products, such as acrolein and other α, β-unsaturated aldehydes, have been implicated as mediators of inflammation and vascular dysfunction. α, β-Unsaturated aldehydes are toxic because of their high reactivity with nucleophiles and their ability to form protein and DNA adducts without prior metabolic activation. This strong reactivity leads to electrophilic stress that disrupts normal cellular function. Furthermore, α, β-unsaturated aldehydes are reported to cause endothelial dysfunction by induction of oxidative stress, redox-sensitive mechanisms, and inflammatory changes such as induction of cyclooxygenase-2 and cytokines. This review provides an overview of the effects of lipid peroxidation products, α, β-unsaturated aldehydes, on inflammation and vascular dysfunction.
( … )
4. Conclusions
Lipid peroxidation-derived α, β-unsaturated aldehydes have been shown to play an important pathophysiological role in vascular diseases. α, β-Unsaturated aldehydes from exogenous and/or endogenous sources, being highly reactive electrophilic molecules, react and modify both proteins and DNA resulting in toxicity. These aldehydes have been implicated in oxidative stress-induced vascular pathologies which act as redox signaling mediators leading to cellular and tissue injury. Furthermore, α, β-unsaturated aldehydes were reported to induce inactivation of antioxidant enzyme such as GPx and TR, activation of NF-κB signaling pathway, and stimulation of inflammatory response through activation of the proinflammatory signaling pathway (Figure 2). Together, results of these studies provide a better understanding of the involvement of LPO-derived α, β-unsaturated aldehydes in vascular dysfunction and their possible role in vascular disease. Understanding the mechanism of inflammation-related vascular dysfunction mediated by LPO-derived α, β-unsaturated aldehydes may help in revealing the pathological factors responsible for vascular diseases and in developing effective therapeutic strategies for these diseases.
( … ).”
Full article/study :
https://pmc.ncbi.nlm.nih.gov/articles/PMC3683506/
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A small explanation regarding the propaganda
by Suavek
To better understand the overall situation of the harmful mechanisms intentionally built into the "COVID" pseudo-vaccines, and especially how propaganda is currently attempting to falsely portray the intentionally harmful design as "unintentional errors," I have selected a study from 2023 for you. Here, we learn, on the one hand, how the "vaccines" disrupt and damage the immune system, and, on the other hand, how supposedly easy it is to modulate the LNPs to make the "vaccination" "safer." I consider this a hoax. If this is really so easy, why weren't the LNPs modulated before the billions of forced injections? The presumed goal behind this is to claim that the "vaccines" that have already been administered were inaccurate because they were supposedly produced in a hurry. The modulation of LNPs is intended to make the mRNA platform medically acceptable again and portray it as "safe and effective." This also aims to conceal the fact that the entire mRNA technology is harmful and useless. Have the perpetrators not yet achieved their intended goal with their murders and reduction of citizens' lifespans? These substances are still on the market and continue to be administered to frightened and unsuspecting people. My private survey, which I conduct on numerous occasions with people I meet by chance, shows that approximately 60-70% of them are fully aware that their normal, seasonal illnesses now last much longer than before and occur much more frequently after the "COVID" injections. Knowledge of the harmfulness of these substances has already become widespread.
Some scientists believe that this technology can only be used in cancer patients whose chances of survival are poor. But even in this area, there are critical voices.
In my observation, the propaganda is trying to focus our attention on LNPs and the DNA contamination. This is intended to make the damage caused by this technology appear to be a manufacturing defect, and above all, to make the other mechanisms of harm that demonstrate the intent to cause harm appear invisible, making us forget about them.
Here is the study that aims to help the harmful technology revive :
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Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Review Article
Published: 02 October 2023
Source : https://www.nature.com/articles/s12276-023-01086-x
“ ( … )
How to control the immunogenicity of LNPs
As previously mentioned, as the immunological activation in response to mRNA-LNP treatment increases, the body’s defense capability may also rise, but there is a high possibility of the mRNA-LNP complexes causing adverse effects, including allergies and autoimmune diseases. To use mRNA-LNPs as a vaccine, immunity must be boosted, and to minimize adverse reactions produced by the repeated delivery of mRNA-LNPs, immunity must be diminished. Therefore, strategies to modulate the immune system are essential. There are ways to control the immune response to mRNA-LNPs including (1) controlling the composition and characteristics of LNPs; (2) using an adjuvant; and (3) regulating the injection route (Fig. 4).
( … )
Adjusting the composition and characteristics of mRNA-LNPs
The physicochemical characteristics of LNPs can be modified by managing the formulation process. During the LNP formulation process, the four lipids can be altered or added to other components, and the composition ratio of each lipid can be modified. Even a slight difference can change the properties of an LNP. For example, changing the molar ratio of PEG or changing the formulation rate changes the size of the LNP in the formulation11,75,76,77. The charge of the LNP is altered by replacing or adding phospholipids to a charged lipid78,79. Moreover, there are techniques for altering PEG lipids80,81.
( … )
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HHS Secretary Robert F. Kennedy Jr. is obviously trying to gain credibility for his department and sends one of his advisors to tell a half-truth :
There's a lot of false information here. The "COVID" disease never existed, and neither did the "SARS-CoV-2 virus." What is referred to here as the "spike protein" is a synthetic protein foreign to humans, artificially produced in the body of the "vaccinated" person, and actually causes serious damage to the body. However, the protein did not originate from a virus. With the statements cited here, it's not really clear to what extent they are clarifications and what percentage are cover-ups. As long as "COVID" and the "SARS-CoV-2 virus" are discussed as if both exist, caution should be exercised regarding the "revelation of the truth." It's well known that propaganda seeks to assume the role of enlightenment by "revealing" the already widely known half of the truth and attempting to conceal the other half. Otherwise, I think the article is quite interesting :
BREAKING: HHS' Top Medical Officer Blasts mRNA Vaccines As Dangerous Experiments
"We’re not seeing a dramatic cancer association with the virus, but we are with the vaccinated people!"
May 14, 2025
https://www.aussie17.com/p/breaking-hhs-top-medical-officer
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Prof. Sucharit Bhakdi warns of mass death
The quality of the video is anything but good, but the text is understandable.
Sucharit Bhakdi relies exclusively on the findings of conventional medicine and comes to the same conclusions regarding the mechanisms of damage as Dr. Mike Yeadon :
Timothy Burchett, March 30, 2025 :
Dr. Sucharit Bhakdi warns of mass death
VIDEO : https://substack.com/profile/104789255-timothy-burchett/note/c-104495943
Another short video with Sucharit Bhakdi, also published by Timothy :
ARE YOU A GMO ?
Apr 04, 2025
VIDEO : https://ohthebastard.substack.com/p/are-you-a-gmo
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UPDATE :
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The next part of this article series has already been published.
Unfortunately, this article could not be sent via email due to excessive data volume. However, it will soon be linked to in several other articles on this Substack :
TOXIC BY DESIGN - PART 24 : The Immune-Damaging Effect of "Covid Vaccination" - A Conversation with Grok (AI)
https://suavek1.substack.com/p/toxic-by-design-part-24-the-immune
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The most reliable information on the “Covid” hoax and the deceptions of the system can be found in the statements of Dr. Mike Yeadon, at the links below :
Dr. Mike Yeadon's Substack #1 :
https://drmikeyeadon.substack.com/
( & https://substack.com/@drmikeyeadon )
The Telegram channel of Dr. Mike Yeadon ( other Telegram channels with his name are fake ! ) :
https://t.me/DrMikeYeadonsolochannel
There is also a chat channel connected to the channel linked above, which is managed by Tim West : https://t.me/DrMikeYeadonsolochannelChat
A collaborative Substack by Dr. Yeadon and Suavek ( Dr. Mike Yeadon's Substack #2 ) :
Fraud Prevention Hotline / suavek1.substack.com
DEAR FRIENDS,
Now that both Substacks, Dr. Yeadon's and Suavek's, have been merged into one enlightening entity ( you can find Dr. Yeadon's explanation here : https://drmikeyeadon.substack.com/p/my-other-substack ), we urge you, if possible, to add both Substacks to your recommended list in your Substack. We both thank you very much in advance,
Mike & Suavek
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The possible support goes to Suavek. I would like to express my sincere thanks to the 27 people who have supported my work so far with 5 euros per month or 50 euros per year.
You can either do something against or for something :
“No one knowing of this would elect to use LNP to formulate anything to be given to entire human populations without let or hindrance, unless they intended harms as a result.”
And so we now know! Harm and harm as in “DEAD” is what they have done! Oh right, what about “31-Million-Lives-Killed?” SNUFFED-OUT?
Now what? Why hasn’t anyone in our political sphere of self-fulfillment, said a damn word? Is it because we’re all “useless-eaters?” Or, are these murderous-mRNA-Bioweapons being normalized, including and most importantly,the end result known as “Death?”
Humanity has reached a tipping point whereas, deliberate & destructive death by “mRNA-Injection,” is being treated as though every unsuspecting
person is to blame!
Will this be their excuse? Is this why they’re silent? How and why this attack against humanity,
has happened is one thing. The simple
fact that it’s been “pigeonholed” by both our president and our HHS Secretary is another story! Not having any answer “why” is much more disturbing
than “how” IMO.
Yes, how this happened? Simply because if they can do once, they’ll do it again! Maybe this time through forced compliance? God knows what has happened is beyond tragic! Beyond anyone’s comprehension, how easily the govt. of the western world nations convinced their people to line up for an unknown, mRNA “Bioweapon-Injection!”
Complicity has many heads, many tentacles and the fact “We the People” haven’t heard a single word from both our President and our HHS Secretary, is admission of guilt! Directly or indirectly.
Look, even if one or both were to address the American people and explain, why this “Weapons of Mass Destruction” attack occurred, maybe just maybe, America would become more united, maybe.
Instead, they’ve continued to distance themselves, distract & deflect attention away from this attack! Why is that?Embarrassment?
I think not! Complicity? Absolutely!
Deliberate Complicity, IMO!
Now, with this much time passed, who in their right mind could possibly accept any answer or excuse or explanation? Who?
What’s so unsettling is, they’ve gotten away with “mass-murder!” With massive amounts of people permanently-disabled! And with the latest data available about sterilization / sterility and or destruction of female egg-production, there’s no doubt in my mind, the table is set for “selective-genetic” reproduction is also a goal of these
“evil-bastards!”
Nobody will be held accountable nor will anyone be held responsible!Remember,
“this attack was done to us not for us!” As everything else they deem necessary for you and me and all the “useless-eaters!”
“God doesn’t sleep!”
May God Bless America and The Entire World!
AJR
I recently experienced extreme vexation ( triggered or ticked off )when I found out about Texas proposed legislation House Bill 6308.
[ See …
Happy Mothers' Day: In honor of mothers whose children were killed and injured by CDC/HHS poisoning schedule.
.....https://sashalatypova.substack.com/p/happy-mothers-day-in-honor-of-mothers/comments.....]
https://dachsie.substack.com/notes
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The main reason I was so ticked off was that I have seen many videos of women who were severely neurologically injured and permanently disabled by having taken the "COVID 19 vaccine." As I think of it now, it seems that almost all those videos and articles I have imbibed since early 2020 were about injuries of women.
Now the politicians are wanting to limit and hold back on monetary awards in the personal injury lawsuits of these victims.
I know there are people of "liberal" political ideas that are also against this effort to demand extensive "proofs" of injury.
I know a little about how political crafty deliberations work and I avoid and want no part of such matters as much as possible.
I see evil and great crafty wrongdoing here. What concerns me is that the medical doctors are so captured or owned that it may be difficult for people severely and permanently injured by the "vaccines" to obtain reasonable and clear substantiation of their injuries. While some of the injuries are clearly evident, others are more hidden to outward appearances, but ALL of them are severe and lifelong disabling and life threatening.
One thing I know, if there is a shred of justice and righteousness remaining in our governmental institutions and entities, these victims deserve the fullest and most generous monetary award. [Now is NOT the time for the Rs to betray their constituency by supporting this poorly motivated legislation of HB 6308.]
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I am filled with thankfulness to God for sending to my awareness the work of Dr. Mike Yeadon and Suavek. Their insights are light and truth for my path. Please keep them in your prayers.
Pray without ceasing and accept and appropriate the grace you receive to the glory of God.
Saint Paul’s letter to the Ephesians
Ephesians 6:12
For our wrestling is not against flesh and blood; but against principalities and powers, against the rulers of the world of this darkness, against the spirits of wickedness in the high places.
https://drbo.org/chapter/56006.htm
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