Form of B12 Deficiency Affecting the Central Nervous System May Be New Autoimmune Disease
Researchers have identified a form of B12 deficiency caused by autoantibodies that specifically affects the central nervous system.
Form of B12 Deficiency Affecting the Central Nervous System May Be New Autoimmune Disease
Lucy Hicks
July 01, 2024
Researchers have identified a form of B12 deficiency caused by autoantibodies that specifically affects the central nervous system.
Discovered while studying a puzzling case of one patient with inexplicable neurological systems, the same autoantibody was detected in a small percentage of healthy individuals and was nearly four times as prevalent in patients with neuropsychiatric systemic lupus erythematosus (SLE) ( https://emedicine.medscape.com/article/332244-overview?form=fpf ).
"I didn't think this single investigation was going to yield a broader phenomenon with other patients," said lead author John Pluvinage, MD, PhD, a neurology resident at the University of California San Francisco, in an interview with Medscape Medical News. "It started as an N-of-one study just based on scientific curiosity."
"It's a beautifully done study," added Betty Diamond, MD, director of the Institute of Molecular Medicine at the Feinstein Institutes for Medical Research in Manhasset, New York, commenting on the research for Medscape Medical News. It uncovers "yet another example of a disease where antibodies getting into the brain are the problem."
The research was published in Science Translational Medicine on June 26.
Full article :
STUDY :
https://www.science.org/doi/10.1126/scitranslmed.adl3758
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